Novel Biomarkers and Therapeutic Options to Address Neuronal Injury
نویسنده
چکیده
Studies show that the aging population is at increased risk for folate deficiency, which may contribute to cognitive decline. Data reveal that with increasing age, serum and cerebrospinal fluid (CSF) folate may drop below normal levels, while serum homocysteine (Hcy), a sensitive marker of functional folate deficiency, may rise to above normal levels. The association between elevated serum Hcy and Alzheimer’s disease (AD) raises the possibility that vitamin therapy to optimize CSF folate or lower Hcy levels may decrease the risk for AD or age-related cognitive decline.
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